CBGA And Painkillers

Painkillers vs. Cannabinoids

Painkillers are the 3rd most prescribed and among the most abused medications in the world. Any measure we can take to eliminate or reduce dependence on these drugs should be explored thoughtfully.

CBGa, CBD, THC, and CBG may possess an excellent analgesic property, but do they mix well with opiates and other painkillers? 

While taking CBD and painkillers might be common already, knowing the risks associated with drug interactions is important. Note that cannabis and cannabinoid therapy is safe as long as we follow the rules. Most cannabis-related deaths arise from the incorrect combination of cannabinoids and other compounds or the consumption of fake cannabis products. 

Similarities between CBGa and Painkillers 

Probably everyone is familiar with some of the most commonly prescribed painkillers available on the market. Over the years, cannabinoids like CBD and CBG have garnered much attention thanks to their numerous therapeutic potentials. For now, there are over a hundred use-cases of cannabinoids, and that list is only getting longer. 

Cannabinoid therapy has continued to explore the possible roles of CBD, THC, and CBG as analgesics. Their ability to block pain transmission and neutralize inflammations and free radicals has continued to gain popularity. Studies show that the endocannabinoid system has a positive interaction with the pain cycle. 

How do Painkillers Work?

The human body metabolizes both CBG and painkillers and inhibits some enzymes before they can be effective.  

Although the effects of CBG and painkillers might come in several ways, studies reveal the results might be similar, but not directly the same. Painkillers trigger pain relief by targeting opioid receptors and inhibiting the effect of cyclo-oxygenase (COX) enzymes. These enzymes are responsible for creating prostaglandins. Prostaglandins are directly linked to pain production and inflammation at injury sites. These receptors are found on the nerve cells in the spinal cord, brain, and other areas within the body. The opioids can further prevent pain messages delivered from the body via the spinal cord to the brain when this occurs.

The final result is effective prevention of the pain you would have felt – therefore, the name “painkiller.” The downside of many painkillers is that they negatively affect liver enzymes. This happens in a liver overworking itself, which is required when processing substances you take. 

Since cannabinoids are painkillers that inhibit the activity of COX-enzymes, there is a possible drug-drug interaction that may produce harmful consequences when taken together. 

Research on CBGa and Pain Response

Although there are limited studies on the analgesic properties of CBGa, research shows it can provide anti-inflammatory and antioxidant properties, which are essential for pain relief. It can inhibit the activity of Cox enzymes and assist with neuropathic pain, chronic pain, and multiple sclerosis. 

Also, CBGa may regulate pain signals from getting to the brain by binding to TPRV1, which causes pain and inflammation. For instance, if you apply a topical CBG balm to an area of your skin, the CBGa will indirectly penetrate the skin and stimulate these various receptors. The result is a decrease in pain signals in that particular area. 

Can I combine CBG with Painkillers?

Before combining any medications, you need to consult with your physician first.

CBGa rosin is very potent. Thus, combining with other medications can spark a drug-drug interaction. This interaction may lead to delayed drug metabolism and possibly overdosing, thus creating more problems. 

A 2019 study showed that adults who use prescription opioids for severe pain are more prone to have increased depression, anxiety, and substance abuse problems if they also take marijuana. Although we don’t precisely know what cannabinoid in the marijuana was responsible for the bad reaction, we must bear in mind that CBG is a component in marijuana. 

So if you’re considering CBGa for pain therapy, please be advised of a possibly increased risk of abuse.


Although CBD and painkillers on their own might be beneficial in treating many health conditions and pain respectively, combining the two may create a negative effect that damages major organs. 

For now, it is recommended you stay off painkillers if you want to try Cannabinoid therapy and vice versa. Feel free to discuss with your physician on the possible use of CBGa as painkillers. 

If you’re ready to try a non-impairing, non-addictive alternative to opiates, CBGa may be right for you. life Research CBGa rosin is the only extract of its kind on the market today. Heat extraction results in a tincture of CBGa, CBG, CBD, CBDa, and powerful terpenes for optimal absorption and analgesic effects.

Feel free to check our store for a list of available products or contact us if you have any questions.