CBGA & the Entourage Effect
Drug-free CBGA brings instant Relief for Inflammatory Symptoms
While we’ve known about Cannabigerol (CBG), the neutral molecule, we’ve never had CBGA, the acid form, before. This molecule is intriguing for several reasons:
- CBGA is the precursor to all other cannabinoids
- CBGA is a non-psychoactive, therapeutic agent which can bind to both CB1 and CB2 receptors3 and has low activity at the CB receptors while stimulating TRPV1, TRPV2, TRPA1, TRP3, TRPV4, and alpha-2 adrenoceptors. CBGA also potently antagonizes TRPV8, suggesting therapeutic potential in prostate cancer, bladder pain, and muscle overactivity.
- CBGA inhibits the uptake of anandamide, serotonin, norepinephrine, and GABA, suggesting potential for mitigating the adverse effects of THC and for its immediate antidepressant effects.
- CBGA demonstrates significant antineoplastic activity; antibacterial effects, including activity against MRSA; and antifungal activity.
- The preceding facts create a new and profound synergy with the “Entourage Effect” that recur with every dose of CGBA.
CBGA has a unique metabolic pathway in that it activates some of the receptors described above over 10,000 times more than CBD. The fact is CBGA has real potential to change the face of human health, but we need more research and clinical trials.
In 1998, Israeli researchers Raphael Mechoulam and S. Ben-Shabat published a ground-breaking study on the “Entourage Effect”. Their paper details complex interactions in which the ratio of certain cannabinoids and their terpenes increase the ECS’s ability to maintain enhanced homeostasis.
CBGA has the unique potential to enhance the Entourage Effect all over the body through a universal cellular metabolism.
Acidic cannabinoids also seem to have greater dose activation than their neutral counterparts.
New research is published daily. There’s no question that CBG is a game changer for cannabis users, health & wellness consumers, and anyone who wants to look, feel, and do their best.